Breakthrough: Scientists first successfully built the original stem cell model - Photo 2.
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Scientists first successfully built the original stem cell model


Cell division is the root of all life. And now, anyone who is interested in this can see firsthand the process of a double, even, cell. "zoom"into the 15 most complex details of the microbiological world inside that cell.

This is thanks to scientists at the Allen Research Institute. For the first time, they created an extremely detailed image combination of a dividing stem cell. These images are something very different from the simple model you often see in high school biology textbooks.

The project promises to reveal many new secrets in the process of miraculous division of life.

Project Original Integrated Stem Cells

Right now, you can visit the project website called Integrated Primary Stem Cell. Here, the tools will allow users to view and rotate detailed stem cell models, reconstructed based on the actual data of human stem cells since they entered until completion of the division process. .

The breakthrough of this project, which had never before been done by any other project, was to combine all the different components in the cell together, to build up the process of an original stem cell. stool. All frames are based on real data, ensuring the objectivity of the process.

Simple simple models are often found in biological textbooks

Every day, there are about 2,000 billion cells in your body, but this complicated process is not easily observed. During mitosis, each cell not only copies its own chromosomes, but also sequences DNA sequences and duplicates many other organelles. When the process ends, they eventually split into two identical daughter cells.

It may sound too easy, but imagine that all of these processes happen under a great amount of time pressure and require rigorous accuracy.

Breakthrough: Scientists first successfully built the stem cell mitosis model - Photo 3.

This is an original image reconstructed from real data

"Biologists have looked at different images of cells, and visualized their relationship for decades. But comparing exactly, we cannot hope that the cell model in the head of each person envisions is the same, "Graham Johnson, a researcher from the Allen Institute for Cell Science, said.

Now, the Allen Institute project finally agreed to all these visualizations. "These visualizations allow us to look directly at many different structures at once, by placing them in the same space. Now scientists can make and discuss more specific, more precise comparisons".

Breakthrough: Scientists first successfully built the stem cell's mitotic model - Photo 4.

Complete 75 "shades" of 15 organelles in 7 phases of cell mitosis

By transforming microscopic images of 15 individual organelles in 7 primary stages, the team created an overview of the division of human pluripotent stem cells (hIPSC).

The details of the process are carefully dissected, where you can see both microtubules, cell membranes, mitochondria, Golgi, actin and nucleoli stand out vividly as they go through each of the phases.

"Once you see this process as a complete picture, you can begin to discover new, unexpected relationships, as well as ask questions and answer completely new questions about the process. Cell division, "said Rick Horwitz, head of Allen Research Institute.

One of the questions Horwitz thought of, was the difference in the process of duplication of normal cells and cancer cells.

Reproduce the entire mitosis process, 7 phases of 15 parts in stem cells

"We are interested in understanding cells overall"The research team member, cell biologist Susanne Rafelski shared. With the model matrix of the Integrated Primary Stem Cell project, Rafelski's wish has been realized.

Now, you can open the site and enjoy the entire cell mitosis process presented in 3D. It will certainly be a very different feeling than looking at the simple models you have seen in high school biology textbooks.

Refer Sciencealert, Bloomberg


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